十博中文官网(中国)控股有限公司

姓　　名：陈建国

技术职称：北京大学生命科学学院教授

电子邮件：chenjg@pku.edu.cn

教育

1989-1994：北京大学生命科学学院（生物系）博士生

1991-1994：东京大学医学部交换学生

1982-1985：浙江农业大学蚕学系（浙江大学动物学院）硕士生

1991-1994：兰州大学生物学理学硕士

1978-1981：苏州蚕桑专科学校（苏州大学生命科学学院）大专生

任职

1999-：北京大学生命科学学院教授

1999--2000：香港科技大学生物学系访问学者

1997--1999：东京大学医学部访问学者

1994--1999：北京大学生命科学学院副教授

1985-1989：浙江农业大学生物技术中心讲师

原始研究论文

1. Feng Qian, Yingying Liu, Xiuxia Liu, Hongkui Deng, Mingxiao Ding, Albert C H Yu and Jianguo Chen. 2006. Baculovirus surface display of SARS Coronavirus (SARS-CoV) spike protein and immunogenicity of the displayed protein in mice model. DNA and Cell Biology. 25（12）: 668-673.

2. Huihui Li, Yan Guo, Junlin Teng, Mingxiao Ding, Albert Cheung Hoi Yu and Jianguo Chen. 2006. 14-3-3_ affects dynamics and integrity of glial filaments by binding to phosphorylated GFAP. J of Cell Science. 119: 4452-4461

3. Chen ZHOU, Chao TAI, Hai-Hong YE, Xi REN, Jianguo CHEN, Shi-Qiang WANG, AND Zhen Chai.2006. Interleukin-1b Downregulates the L-Type Ca2t Channel Activity by Depressing the Expression of Channel Protein in Cortical Neurons. J. OF CELLULAR PHYSIOLOGY. 206(3):799-806.

4. Qian Feng, Huan Yu, Yingying Liu, Chengqiang He, Jingsong Hu, Huachun Sang, Neizheng Ding, Mingxiao Ding, Yin-Wan Wendy Fungc, Lok-Ting Lauc, Albert Cheung-Hoi Yuc, Jianguo Chen. 2004. Genome comparison of a novel foot-and-mouth disease virus with other FMDV strains. BBRC. 323:254-263.

5. Keqiang Fan, Ping Wei, Qian Feng, Sidi Chen, Changkang Huang, Liang Ma, Bing Lai, Jianfeng Pei, Ying Liu, Jianguo Chen, and Luhua Lai. 2004. Biosynthesis, Purification, and Substrate Specificity of Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase. Journal of Biological Chemistry. 279(3):1637–1642.

6. Xi Chen, Qian Feng, Zhiyin Wu, Yingying Liu, Kun Huang, Rui Shi, Sidi Chen, Wen Lu, Mingxiao Ding, Richard A. Collins, Albert Cheung-Hoi Yu and Jianguo Chen. 2003. RNA-dependant RNA Polymerase Gene Sequence from Foot-and Mouth Disease Virus in Hong Kong. BBRC. 308:899-905.

7. Chen XQ, Chen JG, Zhang Y, Hsiao WW and Yu AC 2003. 14-3-3gamma Is upregulated by in vitro ischemia and binds to protein kinase Raf in primary cultures of astrocytes. Glia. 42(4):315-24.

8. Qian Feng, Xi Chen, Ou Ma, Yingying Liu, Mingxiao Ding, ,Richard A. Collins, Lung-Sang Ko, Jun Xing, Lok-Ting Lau, , Albert Cheung Hoi. Yu and Jianguo Chen. 2003. Serotype and VP1 Gene Sequence of a Foot-and-Mouth Disease Virus from Hong Kong (2002). BBRC. 302(4): 715-721.

9. Yan Guo, Chaolaing Wei, Jinsong Hu and Jianguo Chen. Fibrillarin redistributes to the spindle poles and partially colocalizes with NuMA during mitosis. Chinese Science Bulletin. 47:1995-1998.

10. Chengrong Lu, Yong Li, Yanlin Zhao, Guichun Xing, Fei Tang, Qingming Wang,Yuhui Sun, Handong Wei, Xiaoming Yang, Chutse Wu, Jianguo Chen, Kun-liang Guan, Chenggang Zhang, Huipeng Chen, Fuchu He. 2002. Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway. The FASEB J. 16: 90-92

11. Junlin Teng, Yosuke Takei, Akihiro Harada, Takao Nakata, Jianguo Chen and Nobutaka Hirokawa. 2001. Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization. J. Cell Biology. 155(1):65-76.

12. Song huaceng, Zhonghua Lu, Yulong Li, Binggen Ru, Wenqing Wang, and Jianguo Chen. 2001. Phosohorylation of GSK-3 beta in intact cells influences the stability of microtubules. Neuroscience Leter. 312:141-144.

13. Pan Ning, et al. 2000. NF-L and NF-M are expressed in epithelial cells and coassemble with keratin and vimentin. Chinese Science Bulletin. 46（4）：310-312.

14. Chen, J., Nakata, T., Zhang, Z. and Hirokawa, N. 2000. The C-terminal tail domain of neurofilament protein-H (NF-H) forms the crossbridges and regulates neurofilament bundle formation. Journal of Cell Science 113, 3861-3869.

15. Yang Xiaoyong, Junlin Teng, Yang Jin and Jianguo Chen. 1999. MAP2c confers drug stability to microtubules in vivo. Chinese Science Bulletin. 44(23):2162-2167.

16. Tong Xiangjun, Jianguo Chen, Jie Liu, Shijin Pang and Zhonghe Zhai. 1999. Assembly and structure of neurofilaments isolated from bovine spinal cord. Science in China.42(3): 233-239.

17. Tong Xiangjun, Zhonghe Zhai and Jianguo Chen. 1999. Coil-1 of rod domain of NF-L is essential for its assembly in vivo. Science in China. 42(5): 449-456.

18. Terunaga Nakagawa, Jianguo Chen, Zhizeng Zhang, Yoshimitsu Kanai, and Nobutaka Hirokawa. (1995). Two Distinct Function of the Carboxyl-terminal Tail Domain of NF-M upon Neurofilament Assembly: Cross-bridge Formation and Longitudinal Elongation of Filaments. J. Cell Biol., 129:411-429.

19. Kanai, Y., Chen, J. and Hirokawa, N. (1992). Microtubule bundling by tau proteins in vivo: analysis of functional domains. EMBO J. 11, 3953 - 3961.

20. Chen, J., Kanai, Y., Cowan, N. J. and Hirokawa, N. (1992). Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons. Nature. 360, 674 - 677.

综述

1. 佟向军，陈建国，翟中和：神经丝的结构和功能,《细胞生物学动态》（第二卷），主编：翟中和。北京师范大学出版社，1997。

2. 陈建国，翟中和：中间纤维的分子生物学,《细生物学进展》（第三卷），主编：郑国錩，翟中和。高等教育出版社，1993.

3. 佟向军，陈建国，翟中和. 1998. 神经丝的结构与功能（综述）. 细胞生物学杂志. 20(2):63-68.

4. 丁明孝，陆宇，陈建国. 1996. 猪瘟病毒及其疫苗研究进展. 中国病毒学. 11(3):201-207.

书

1. 《细胞生物学》第三版，主编：翟中和等。高等教学出版社，2007。

2. 《细胞分子生物学》主编：陈晔光等。（滕俊琳，陈建国：微管和细胞质物质运输系统）清华大学出版社，2006。

3. 《神经科学进展（III）》，主编：王晓明等，（滕俊琳，陈建国：微管相关蛋白与神经细胞的形态构建），高等教学出版社，2004。

4. 《当代生物学》，主编：邹承鲁，（细胞生物学学科责任编委）。中国致公出版社，北京，2000。